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    2022-09-27 06:07:50÷˹ҽѧ
    ʾΰΪȫΧڷʼߵĶ벻׼߶ԣҪ֧ܾгȡı걾вжϡ

    ΰΪȫΧڷʼߵĶ벻׼߶ԣҪ֧ܾгȡı걾вжϡ

    ġ׼鶼ֻҽ֡жϲ飬ƹиЧCTMRIȣʹӰϷ׿顢жϲʡͣȷﻹҪϡһΪ󲿷֣

    걾һϢ


    ΢DZ걾Ĵ֯ж󣬰λáСǷ⻬߽ǷΧΧܰͽȣ

    ϲ֡⾵Dzҽһ΢۲쵽ϸҪϸСʡĤԼϸʽȣЩһ㲻ڲֻһŲɫ / ڰ׵ͼƬΰҪIJ־Dzϲ֣ı걾ǷжϸԼϸԴ֯򵥵˵ȷDzǷΰСϸǷСϸ۰ٰ⣬䲻ͣڲлϵݣļϳ黯ķʵ֡һ㶼г黯Ŀԭʣôΰij黯ָνʲôأ黯֯ѧ⣬DzһֳõļֶΡͼı걾С걾Ǵ걾ƬȾɫݻѧӦʹǿɫɫԴȷ֯ϸڵĿԭжλԼо黯ڲļϡΰ͵жϣԷΰƶʮаġ⣬黯ڷΰӷ͵жϣ黯ķл⡣һ黯С+-ʾʲô

    +黯ɫΪԣҲָблͻ䣻

    -ʾҲ޷Ⱦɫޱ޻ͻ䡣黯ָЩ

    1p63/p40CK5/6TTF-1 ҽٰ۰ⷽʽȷΰ۰ٰ͡

    1TTF-1 ڳ 70% ķճҺٰбСϸΰСδֻϸΰͷǵ఩఩ TTF-1۰ĤƤԼεתٰУTTF-1 ԡ2p63/p40ڳ 90% ķ۰ϸǿԣ 10%-33% ķٰʾԵˮƽP40 P63 ׵ͣλϸˡP40Ժߵ۰־ P63 ȣP40 ڷ۰е P63 ൱ڷٰܰмʶҲܸߡ3CK5/6 ʱҪ״ƤϸƤϸƤϸͼƤϸС 75% ķ۰CK5/6ԣƤƤ߱2%-33% ķٰԡ4DSG3оǵף85%-90% ۰бٰ<2%2Ki-67 ֳָϸֳйصָ꣬ԽߣԽ죬ֻ֯ԽԻҲԽСڷKi-67Ϻͷּ఩ Ki-67 5%ڵͼ𣬷ǵ఩ԼΪ 5%-20%м𣬴ϸΰ 60%ڸ߼3ٴƼ(ER)м(PR)CA199CEAPSAVIMȣ ǷתԷΰԼתưԭʲôһԣתƵεٰٰٰCA199CEAǰٰPSAPAPӹٰCEAVIMӹĤVIM᳦ٰCA199CEACDX2ƤCK5/6WT1VIMͨתԭйͬĿԭ۰ʳܡͷƤȲλĿǰЧı־ڷԭ۰ת۰ļ𣨿ѧҪŬ4ALKEGFR EGFRALKǷΰгͣضİϸĻ죬ЩӰư֢ѷʽĿǰȫ綼ƼΰһҪȥΪһͻԣ߿ʹðҩٰпչļ϶࣬ΪַΰЩͻӰ졣Щ£⣿没Ϻϻٰ۰ȣŽ⡣EGFRALKĻȷָϺרҹʶƼйEGFRALKNSCLCϼָϡƼٰߺٰɷֵķΰԭ϶ҪEGFRALK⡣⣬ǰƼ۰⣬ָָȡС걾۰ܻӲٰˣʹС걾вΪ۰ĻߣDz̵ŮԣΪʱALK⡣

    ̱걾ҲEGFRALK⡣ֵעǣ걾ڱ걾㣬ʲô⣬С걾ڱ걾ޣڽмǰҪ淶Ҫ棺

    һȡı걾û

    ڶĺǷʺ⣬ΪҪ㹻ϸȡDNAСˣС걾ǰEDzʿغҪIJ֡ϸ񡢹淶С걾ûκл⣬걾ͬļⷽ׼ȷԺʹ걾֮û̫졣ġEGFRڷΰеͻEGFRǷΰгһͻкܶƬΣÿƬε쳣ٴҩһָ塣EGFRд󲿷ֵĻƬͻ䣬ڷͻ䡣EGFR-E746EGFR-L858EGFRУһЩƬλ㣬EGFR-E746EGFR-L858֡+ʱ˵лͻ䣬֡ʱ˵ûлͻ䡣λ⣬Ҫλ㣬鿴λӦĻƬǷͻ䡣ijЩƬδڻͻʱһҪʱѯٴҽʦ߲ҽʦƬλͻǷʺʹðҩҽרҵĽ顣ĿǰйרҹʶУƼ֯ѧ(IHC)ۺøӦ(PCR)Լӫԭλӽ(FISH)ȷALKֻҪƼķκһַALKΪԣʾҪаơڼⷽУһֱȽϳõ黯ΪVentana IHCͨVentana IHCALKΪʱֱӽкİƣӼ⡣塢ͬⷽҪʱҲһԼALKΪ

    Ventana IHC黯Լ12ͿԳ

    FISHӫԭλӽʱҪ34

    PCRۺøӦֱȽϸӵķѧⷽԼҪ57ճҪ֮ڳ׼ȷʸκһѧⷽ׼ȷʶܴﵽ100%ǣĿǰʡڹʶƼʹõĻⷽǾʵ֤ٴģܺܺõرĻ״̬ԣȻͬĻⷽԡ֮в𣬵ԣֻҪͨ˹ҹٷ֤ļ⼼ʹáߡνĽӦרҵҽΪҽݻߵĸ׼ȷжϡÿϸĶԳ̶ȺйϵҪΰĻߣǰһҪϸ߸ز͸ǿ CTٰһͷ CTֹͷۣһҪȥɨ衣ΰ߿ʼðҩûзҩĻҽὨ黼߳á

    οף1.J Thorac Oncol. 2019 Mar;14(3)377-407.Best PracticesRecommendations for Diagnostic Immunohistochemistry in Lung Cancer.2.Lancet Oncol. 2012 Jan;13(1)e23-31.EGFR exon 20 insertionmutations in non-small-cell lung cancer preclinical data and clinicalimplications.3.Mol Cancer. 2018 Feb19;17(1)52.The function and therapeutic targeting of anaplastic lymphomakinase (ALK) in non-small cell lung cancer (NSCLC).

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    йȵĽŻվйǿ2022-09-27ͨйʷƾáģӵзḻӴûĽƽ̨ڽѶҽʴ𡢾ҽҩϢѯȷȣ߽Ϣ¶ȸdz4û

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